Jab1/CSN5 regulates PD-L1 in T-cell lymphomas and leukemias

BestPractice | Jun 2019 | EHA 2019 |

Jab1/CSN5 regulates PD-L1 through stabilization of the protein and can be efficiently targeted by CSN5i3 in preclinical models of T-cell lymphomas and leukemias. Jab1/CSN5 expression significantly correlates with PD-L1 protein levels and STAT3 activation in peripheral T-cell lymphomas.